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. 1997 Jul 15;17(14):5591–5598. doi: 10.1523/JNEUROSCI.17-14-05591.1997

Fig. 2.

Fig. 2.

Local application of FFA causes an increase in population spike response to PP stimulation. FFA leaked through the recording pipette while measuring electrophysiological response to PP stimulation. A, A marked increase in population spike is seen with all stimulation intensities, by comparison to a control pipette, used at the same recording location. B, This is not accompanied by a change in population EPSPs. Insetillustrates sample responses recorded with NaCl- and FFA-containing pipettes alternately at the same site. Note the large increase in population spike in the presence of FFA. C, Insertion of a recording pipette at the site that was recorded previously with an NaCl-containing pipette shows a larger population spike with the same EPSP (as in inset in B). Replacement of the recording drug-containing pipette with an NaCl-containing pipette restored the original population spike. This procedure can be repeated several times with considerable stability.