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The effect of FFA is mimicked by local application of the 5-HT1a agonist 8-OHDPAT, but not by its systemic application. Input–output relationships are depicted in control, after systemic application of the drug, after its local application, and after its systemic application in animals depleted of serotonin by treatment with PCPA. A marked suppression of population spike is seen with peripheral application of the drug, which is reversed into enhancement in PCPA-treated rats.
