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. 1997 Jul 15;17(14):5349–5356. doi: 10.1523/JNEUROSCI.17-14-05349.1997

Fig. 7.

Fig. 7.

Summary of the effects of CYZ on accommodation and LTD. A, Group data (n = 5) showing the abolition of LFS-induced LTD, but not accommodation, after application of CYZ. Responses under CYZ represent averages of both evoked EPSPs and action potentials from all neurons. Note that neuronal excitability continued to increase under CYZ after termination of LFS.B, Synaptic strength at the end of LFS period was not statistically different under CYZ (38.7.8 ± 6.3% control) than in untreated groups (see Fig. 3A;p > 0.1; two-tailed t test).Dashed line indicates predicted response under CYZ if the site of accommodation was presynaptic, assuming that the effect of LFS was independent of CYZ. Data are replotted from Figures 3 and7A with all data points corresponding to neuronal firing being removed. C, Synaptic strength under CYZ was not depressed after LFS. Data represent averages in the control period and 5 and 15 min after LFS (Post-LFS). None of the cells under CYZ exhibited type II behavior despite variable effects of CYZ on EPSPs.