Behavioral progression of seizure activity.A, NGF administration accelerates the behavioral progression of kindling. Values represent mean seizure stage ± SEM for NGF-kindled (NGF; n = 7), cytochrome C-kindled (CYT-C; n = 5), and PBS-kindled (PBS; n = 6) animals. B, The mean number of stimulations to reach a stage 5 seizure was calculated for all groups, and data were subjected to a one-way ANOVA with post hoc Tukey tests. NGF-infused rats (NGF; n = 7) required ∼45% fewer stimulations to reach a stage 5 seizure, as compared with rats infused with PBS (PBS; n = 6) or cytochrome C (CYT-C; n = 5) (p < 0.05). Values represent the mean number of stimulations ± SEM required to reach a stage 5 seizure.