Fig 6. In vivo evaluation of the synergic effects of celecoxib and radiation therapy in A549 xenografts.
Growth curves of lung cancer xenografts in nude mice established by injection of 1 × 107 A549 cells in the flanks of nude mice and tumors were allowed to develop. Celecoxib was injected into the tail vein at day 0 when the mean tumor diameter was ~5 mm, and the tumor diameter was measured every other day. Irradiated at 10 Gy for three times with a 7-days of interval. Each group consisted of 6 animals and data are represented as mean ±SD. ***P<0.001 vs. control at day 10; ###P<0.001 vs. radiation only at day 20. Representative images of tumor in each group were shown (bar = 1 cm), tumor from control group was obtained from day 10, tumors from two other groups were from day 20.