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. 1997 Oct 15;17(20):7583–7593. doi: 10.1523/JNEUROSCI.17-20-07583.1997

Fig. 4.

Fig. 4.

Identification of mutations that disrupt the negative effects of the GAP-43 repressive element. A, The GAP-43 repressive element is shown downstream of the TK promoter. Sequences that were mutated to produce new promoter constructs areunderlined (sites A-D), and the mutant sequences are given in lower-case letters.Brackets enclose a 9 bp sequence with similarity to the NGFI-A/EGR consensus sequence. B, TK promoters with the repressive element and the indicated mutations were tested for activity in neurons and hepatoma cells (same as Fig. 1), and activity in each cell type is reported a percent of the activity of the entirely wild-type TK promoter. Mutation C was not tested on its own in this context. C, The ratio of activity in neurons to activity in hepatoma cells is reported for each promoter construct.

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