Table 1.

Regulation of cAMP pathway proteins in the LC by chronic morphine administration

	Protein immunoreactivity
Adenylyl cyclase
Type I	126  ± 6 (19)*
Type III	89  ± 5 (6)
Type IV	104  ± 4 (6)
Type V	93  ± 3 (6)
Type VIII	124  ± 7 (12)*
Protein kinase A
Catalytic subunit	141  ± 7 (12)*
Regulatory subunit type I	104  ± 9 (12)
Regulatory subunit type II	133  ± 6 (12)*
Giα	134  ± 7 (6)*
Tyrosine hydroxylase	153  ± 8 (6)*
CREB	142  ± 9 (6)*

Data are expressed as mean ± SEM percent of control (n). Results on tyrosine hydroxylase and CREB represent replications of published findings (Guitart et al., 1990; Widnell et al., 1994).

^* p < 0.05 by t test.