Table 2.

Regulation of cAMP pathway proteins in the LC by 5 d of intra-LC infusion of antisense oligonucleotide to CREB: effects in drug-naive rats

	Antisense	Sense	Missense	AS-reversal
Adenylyl cyclase
Type VIII	73  ± 7 (6)*	104  ± 7 (6)	106  ± 11 (5)
Type I	79  ± 7 (6)2-160
Type III	95  ± 8 (6)
Protein kinase A
Catalytic subunit	87  ± 3 (11)2-160	100  ± 6 (8)	107  ± 11 (6)	103  ± 15 (6)
Regulatory subunit type II	85  ± 3 (6)2-160	95  ± 14 (6)
Giα	94  ± 14 (6)	97  ± 12 (8)	103  ± 8 (6)	113  ± 12 (6)
Tyrosine hydroxylase	82  ± 3 (6)*	102  ± 11 (6)	107  ± 12 (7)	108  ± 14 (6)

Data are expressed as mean ± SEM percent of contralateral uninfused side (n). Antisense, sense, and missense refer to intra-LC infusion of antisense, sense, or missense oligonucleotide, respectively. AS-reversal refers to intra-LC infusion of antisense oligonucleotide for 5 d followed by 5 d of vehicle infusion.

^* p < 0.05;

F2-160:  p ≈ 0.1 byt test.