Table 3.

Regulation of cAMP pathway proteins in the LC by 5 d of intra-LC infusion of antisense oligonucleotide to CREB: effects in chronic morphine-treated rats

	Antisense	Sense	Missense
Adenylyl cyclase
Type VIII	45  ± 4 (5)3-150	97  ± 10 (4)	100  ± 6 (6)
Type I	107  ± 6 (6)
Type III	102  ± 10 (6)
Protein kinase A
Catalytic subunit	88  ± 8 (12)	95  ± 2 (5)	104  ± 10 (5)
Regulatory subunit  type II	86  ± 12 (6)	94  ± 7 (4)
Giα	83  ± 12 (12)	104  ± 10 (5)
Tyrosine hydroxylase	54  ± 8 (10)3-150	102  ± 2 (4)	110  ± 12 (4)

Data are expressed as mean ± SEM (n). Antisense, sense, and missense refer to intra-LC infusion of antisense, sense, or missense oligonucleotide, respectively.

F3-150:  p < 0.05 by t test.