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. 1997 Oct 15;17(20):8018–8023. doi: 10.1523/JNEUROSCI.17-20-08018.1997

Fig. 2.

Fig. 2.

Calcium but not PKC or NO plays a role in the expression of peripheral opioid tolerance. Effects of PGE2, (PGE2;n = 16), DAMGO plus PGE2(DAMGO+PGE2; n = 16), three hourly injections of DAMGO followed by DAMGO plus PGE2(DAMGO×3, DAMGO+PGE2;n = 12), three hourly injections of DAMGO followed by TMB-8 plus DAMGO plus PGE2 at the fourth hour (DAMGO×3,TMB+DAMGO+PGE2;n = 6), three hourly injections of DAMGO followed by Quin-2 plus DAMGO plus PGE2 at the fourth hour (DAMGO×3,Quin+DAMGO+PGE2;n = 6), three hourly injections of DAMGO followed by chelerythrine plus DAMGO plus PGE2 at the fourth hour (DAMGO×3,Ch+DAMGO+PGE2;n = 12), and three hourly injections of DAMGO followed by NMLA plus DAMGO plus PGE2 at the fourth hour (DAMGO×3,NMLA+DAMGO+PGE2;n = 6) on mechanical paw withdrawal threshold in rats.