Figure 10.

Ro 65–6570 attenuated LID in MPTP-treated macaques. Five stably parkinsonian macaques were made dyskinetic by chronic l-DOPA treatment, and then challenged with l-DOPA combined with Ro 65–6570 (0.001 and 0.01 mg/kg, i.m.) or saline (A). Dyskinetic conditions were assessed on a Dyskinesia Disability Scale (see Materials and Methods) evaluating choreiform and dystonic components (A, B). The time courses of these motor responses are shown in C and D. Data are expressed as absolute dyskinesia scores in each animal (A), medians with lower and upper quartiles (B), or means ± SEM (C, D). Statistical analysis was performed by one-way nonparametric RM ANOVA (Friedman test) followed by the Dunn's test for multiple comparisons. *p < 0.05, significantly different from saline.