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. 2012 Nov 14;32(46):16106–16119. doi: 10.1523/JNEUROSCI.6408-11.2012

Figure 7.

Figure 7.

N/OFQ attenuated LID when injected in SNr and DLS. Effect of N/OFQ (0.03–1 nmol, i.c.v.) injected in SNr (A), DLS (B), or both (at 0.1 nmol; C) on ALO AIMs induced by l-DOPA (6 mg/kg plus benserazide 15 mg/kg, i.p.). N/OFQ given 5 min before l-DOPA attenuated the severity of dyskinesias in a dose-related fashion, being more potent when injected in DLS than SNr. Coinjection of N/OFQ in SNr and DLS produced an additive antidyskinetic effect (C). Saline was simultaneously injected in SNr and DLS. Data are expressed as percentage of the l-DOPA effect measured in the same animal in the last training session, and represent the mean ± SEM of 10 determinations. Statistical analysis was performed by one-way (A, B) or two-way (C) ANOVA followed by the Newman–Keuls test for multiple comparisons. A, Significant effect of treatment (F(11,71) = 9.58, p < 0.0001). B, Significant effect of treatment (F(11,71) = 38.8, p < 0.0001). C, Main effect of N/OFQ (F(3,60) = 528.64, p < 0.0001), brain area (F(2,60) = 33.94, p < 0.0001), and their interaction (F(6,60) = 23.76, p < 0.0001). **p < 0.01, *p < 0.05, significantly different from saline. °°p < 0.01, significantly different from SNr injection. ##p < 0.01, significantly different from DLS injection.