Figure 1. TRIM21 is a highly conserved gene.

Conservation of TRIM21 compared to invariant housekeeping genes (HDACs and actins), and immune genes including CGAS, STING and related TRIMs, TRIM5 and TRIM20. Comparison of variants between genes is expressed as number of missense variants (MVs) per 100 residues to normalize for differences in gene length (A-B). Frequency of nonsynonymous variants (A) common variants (≥1%) and (B) rare variants (<1%). Error bars represent standard deviation. Data provided in Figure 1—source data 1.