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. 2019 Oct 15;8:e50069. doi: 10.7554/eLife.50069

Figure 1. Metabolomics profile of GRU102 and its transgenic controls (GRU101).

(A) Acylcarnitines (AC) profile, (B) Triacylglyceride (TAG), (C) Total Amino acids (AA) level, (D) Percentage glucogenic AA, computed as [sum of AA forming the particular glucogenic substrate/total AA levels]. (E) Organic acids (OA) concentration of GRU101 and GRU102. All values were normalized to respective protein concentration and then to young GRU101 (Two-way ANOVA Dunnett’s multiple comparisons test, p<0.05, *; p<0.005, **; p<0.001, ***; n = 3 repeats per condition, with approximately 3000 animals per repeat collected from independent cohort). Similar results have been confirmed in one other independent trial (Figure 1—figure supplement 1).

Figure 1—source data 1. Metabolomics data for D4 and D12 GRU101 and GRU102.
All data were normalized to D4 GRU101.
elife-50069-fig1-data1.xlsx (54.8KB, xlsx)
DOI: 10.7554/eLife.50069.004

Figure 1.

Figure 1—figure supplement 1. Metabolomics profile of GRU102 and its transgenic controls (GRU101) (independent repeat).

Figure 1—figure supplement 1.

(A) Acylcarnitines (AC) profile, (B) Total Amino acids (AA) level, (C) Percentage glucogenic AA, computed as [sum of AA forming the particular glucogenic substrate/total AA levels] (D) Organic acids (OA) concentration of GRU101 and GRU102. All values were normalized to respective protein concentration and then to young GRU101 (Two-way ANOVA Dunnett’s multiple comparisons test, p<0.05, *; p<0.005, **; p<0.001, ***; n = 3 repeats per condition, with approximately 3000 animals per repeat collected from independent cohort).