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. 2019 Oct 15;200(8):992–1001. doi: 10.1164/rccm.201812-2351OC

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Copyright © 2019 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — PZP (pregnancy zone protein) is a cytoplasmic and nuclear protein that is released in neutrophil extracellular traps (NETs). (A) In patients with bronchiectasis, extracellular PZP correlates with markers of NET formation. (B) Peripheral blood neutrophils were induced to undergo NET formation with 600 nM phorbol myristol acetate for 4 hours. The NETs contain PZP. (C and D) Electron microscopy of neutrophils (C) and neutrophils plus eosinophils (D) showing diffuse cytoplasmic and nuclear staining for PZP (black dots).