Figure 7.

Schematic diagram shows the proposed molecular mechanisms whereby FOXF1 regulates STAT3 signaling and pulmonary angiogenesis. FOXF1 induces transcription of Stat3 gene leading to increased expression of cell cycle regulatory genes (Ccnb1, Ccnd1, and c-Myc). FOXF1 physically binds the STAT3 protein and these protein-protein interactions are dependent on Serine 52 of FOXF1. Increased STAT3 signaling leads to activation of endothelial cell proliferation and increased angiogenesis. FOXF1 regulates other proangiogenic genes independently of STAT3. S52 = Serine 52.