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. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: Neuropharmacology. 2018 Jun 5;138:130–139. doi: 10.1016/j.neuropharm.2018.06.003

Fig. 5.

Fig. 5.

Effect of parecoxib (25 mg/kg, i.v.), administered over 45 min, on A) firing rate and B) burst firing of VTA DA neurons in WT (n = 6–7) and KMO K/O (n = 6–8) mice. In A, the percent change in firing rate at different timepoints was compared to the corresponding value before the administration of parecoxib (***p < 0.001, *p < 0.05, Mann–Whitney U test). The change in firing rate between WT and KMO K/O mice was compared at corresponding timepoints (++p < 0.01, +p < 0.05, Mann–Whitney U test). In B, burst firing was compared within subjects to the basal value before parecoxib administration (*p < 0.05, Wilcoxon matched pairs sign rank test). Each value is the mean ± SEM.