Figure 3.

Case 2. Patient background characteristics at the commencement of glecaprevir/pibrentasvir and sequences of amino acids 21-140 in the non-structural protein 5A region at the commencement of direct-acting antiviral agent treatment and re-elevation of viral loads. Dashes indicate amino acids identical to the sequence of HCV-J (accession no. D90208) (3). Substituted amino acids are indicated by standard single-letter codes. aa: amino acids, DCV/ASV: daclatasvir/asunaprevir, D/A/B, DCV/ASV/BCV: daclatasvir/asunaprevir/beclabuvir, FIB-4: fibrosis-4, G/P, GLE/PIB: glecaprevir/pibrentasvir, NS: non-structural protein, RAVs: resistance-associated variants, L/S, LDV/SOF: ledipasvir/sofosbuvir