Table 1.
Patient characteristics according to CHA2DS2-VASc score
| Overall | CHA2DS2-VASc score | |||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3–5 | 6–9 | ||
| No. of patients (%) | 7141 (100.0) | 222 (3.1) | 750 (10.5) | 1317 (18.4) | 4087 (57.2) | 765 (10.7) |
| Sex (female) | 2303 (32.3) | 0 (0.0) | 64 (8.5) | 250 (19.0) | 1551 (37.9) | 438 (57.3) |
| Age (years) | ||||||
| < 65 | 1436 (20.1) | 222 (100.0) | 481 (64.1) | 400 (30.4) | 327 (8.0) | 6 (0.8) |
| 65–74 | 2786 (39.0) | 0 (0.0) | 269 (35.9) | 781 (59.3) | 1646 (40.3) | 90 (11.8) |
| ≥ 65 | 5705 (79.9) | 0 (0.0) | 269 (35.9) | 917 (69.6) | 3760 (92.0) | 759 (99.2) |
| ≥ 75 | 2919 (40.9) | 0 (0.0) | 0 (0.0) | 136 (10.3) | 2114 (51.7) | 669 (87.5) |
| Body weight (kg) | ||||||
| ≥ 60 | 4047 (59.0) | 186 (89.0) | 569 (79.9) | 887 (70.8) | 2113 (53.6) | 292 (39.2) |
| 50–59 | 1855 (27.0) | 22 (10.5) | 121 (17.0) | 284 (22.7) | 1177 (29.9) | 251 (33.7) |
| < 50 | 956 (13.9) | 1 (0.5) | 22 (3.1) | 82 (6.5) | 650 (16.5) | 201 (27.0) |
| SBP (mmHg) ≥ 160 | 310 (4.6) | 3 (1.5) | 14 (2.0) | 41 (3.3) | 203 (5.2) | 49 (6.7) |
| CrCl (mL/min) | ||||||
| ≥ 50 | 5326 (78.3) | 204 (100.0) | 692 (98.0) | 1153 (93.0) | 2874 (73.4) | 403 (54.3) |
| 30–49 | 1347 (19.8) | 0 (0.0) | 14 (2.0) | 83 (6.7) | 952 (24.3) | 298 (40.2) |
| < 30 | 133 (2.0) | 0 (0.0) | 0 (0.0) | 4 (0.3) | 88 (2.2) | 41 (5.5) |
| CHADS2 score | ||||||
| < 2 | 2667 (37.3) | 222 (100.0) | 750 (100.0) | 1080 (82.0) | 615 (15.0) | 0 (0.0) |
| 2 | 2064 (28.9) | 0 (0.0) | 0 (0.0) | 237 (18.0) | 1827 (44.7) | 0 (0.0) |
| ≥ 3 | 2410 (33.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1645 (40.2) | 765 (100.0) |
| HAS-BLED score | ||||||
| < 3 | 5928 (88.8) | 191 (99.5) | 673 (98.5) | 1163 (96.0) | 3421 (88.7) | 480 (65.8) |
| ≥ 3 | 746 (11.2) | 1 (0.5) | 10 (1.5) | 49 (4.0) | 436 (11.3) | 250 (34.2) |
| Comorbidity | ||||||
| CHF | 1864 (26.1) | 0 (0.0) | 53 (7.1) | 180 (13.7) | 1217 (29.8) | 414 (54.1) |
| Hypertension | 5065 (70.9) | 0 (0.0) | 316 (42.1) | 810 (61.5) | 3229 (79.0) | 710 (92.8) |
| Angina pectoris | 833 (11.7) | 0 (0.0) | 2 (0.3) | 48 (3.6) | 538 (13.2) | 245 (32.0) |
| Diabetes mellitus | 1737 (24.3) | 0 (0.0) | 46 (6.1) | 185 (14.0) | 1099 (26.9) | 407 (53.2) |
| PAD | 187 (2.6) | 0 (0.0) | 0 (0.0) | 12 (0.9) | 112 (2.7) | 63 (8.2) |
| Aortic aneurysm | 98 (1.4) | 0 (0.0) | 0 (0.0) | 6 (0.5) | 67 (1.6) | 25 (3.3) |
| Deep vein thrombosis | 37 (0.5) | 1 (0.5) | 1 (0.1) | 2 (0.2) | 20 (0.5) | 13 (1.7) |
| Pulmonary embolism | 18 (0.3) | 0 (0.0) | 1 (0.1) | 2 (0.2) | 12 (0.3) | 3 (0.4) |
| Dyslipidemia | 2995 (41.9) | 62 (27.9) | 228 (30.4) | 516 (39.2) | 1788 (43.7) | 401 (52.4) |
| Liver dysfunction | 413 (5.8) | 13 (5.9) | 41 (5.5) | 91 (6.9) | 240 (5.9) | 28 (3.7) |
| Renal dysfunction | 7 (0.1) | 0 (0.0) | 0 (0.0) | 1 (0.1) | 5 (0.1) | 1 (0.1) |
| Medical history | ||||||
| Ischemic stroke | 1440 (20.2) | 0 (0.0) | 0 (0.0) | 39 (3.0) | 860 (21.0) | 541 (70.7) |
| Hemorrhagic stroke | 135 (1.9) | 1 (0.5) | 9 (1.2) | 15 (1.1) | 89 (2.2) | 21 (2.7) |
| Transient ischemic attack | 219 (3.1) | 0 (0.0) | 0 (0.0) | 6 (0.5) | 132 (3.2) | 81 (10.6) |
| Systemic embolism | 59 (0.8) | 0 (0.0) | 6 (0.8) | 6 (0.5) | 33 (0.8) | 14 (1.8) |
| Myocardial infarction | 298 (4.2) | 0 (0.0) | 0 (0.0) | 9 (0.7) | 207 (5.1) | 82 (10.7) |
| Malignant tumor | 654 (9.2) | 13 (5.9) | 59 (7.9) | 116 (8.8) | 388 (9.5) | 78 (10.2) |
| Bleeding/disposition of bleeding | 292 (4.1) | 5 (2.3) | 21 (2.8) | 48 (3.6) | 179 (4.4) | 39 (5.1) |
| Rivaroxaban dosage 15 mg/day | 4036 (56.5) | 198 (89.2) | 639 (85.2) | 950 (72.1) | 2024 (49.5) | 225 (29.4) |
| Amount of drinking (unit/week) | ||||||
| Nondrinker | 3798 (53.2) | 65 (29.3) | 247 (32.9) | 518 (39.3) | 2410 (59.0) | 558 (72.9) |
| < 8 | 2402 (33.6) | 112 (50.5) | 303 (40.4) | 556 (42.2) | 1261 (30.9) | 170 (22.2) |
| ≥ 8 | 941 (13.2) | 45 (20.3) | 200 (26.7) | 243 (18.5) | 416 (10.2) | 37 (4.8) |
| History of smoking | ||||||
| Nonsmoker | 4318 (60.5) | 115 (51.8) | 371 (49.5) | 706 (53.6) | 2568 (62.8) | 558 (72.9) |
| In the past | 2097 (29.4) | 63 (28.4) | 242 (32.3) | 428 (32.5) | 1199 (29.3) | 165 (21.6) |
| Current | 726 (10.2) | 44 (19.8) | 137 (18.3) | 183 (13.9) | 320 (7.8) | 42 (5.5) |
| Type of AF | ||||||
| Non-PAFa | 3940 (55.2) | 119 (53.6) | 392 (52.3) | 659 (50.0) | 2296 (56.2) | 474 (62.0) |
| Using concomitant anti-platelets | 1029 (14.4) | 2 (0.9) | 23 (3.1) | 92 (7.0) | 669 (16.4) | 243 (31.8) |
| Using concomitant NSAIDs | 165 (2.3) | 4 (1.8) | 12 (1.6) | 22 (1.7) | 96 (2.3) | 31 (4.1) |
SBP systolic blood pressure, CrCl creatinine clearance, CHF congestive heart failure, PAD peripheral arterial disease, AF atrial fibrillation, PAF paroxysmal atrial fibrillation, NSAIDs non-steroidal anti-inflammatory drugs
aPersistent and permanent atrial fibrillation