Table 1.

Eculizumab dosage regimen, standard therapy according to EMA/FDA

Weight category	Induction phase	Maintenance phase
Above 40 kg	900 mg, every week, for 4 weeks	1200 mg, in fifth week, every 14 days thereafter
30 to < 40 kg	600 mg, every week, for 2 weeks	900 mg, in third week, every 14 days thereafter
20 to < 30 kg	600 mg every week, for 2 weeks	600 mg, in third week, every 14 days thereafter
10 to < 20 kg	300 mg once	300 mg, in second week, every 14 days thereafter
5 to < 10 kg	300 mg once	300 mg, in second week, every 31 days thereafter

Eculizumab has to be administrated intravenously

EMA European Medicines Agency, FDA Food and Drug Administration