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. 2019 Oct 15;9:14829. doi: 10.1038/s41598-019-51339-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ex vivo frequency of CD14⁺⁺CD16⁻ monocytes in peripheral blood directly correlates with the capacity of activated monocytes to produce pro-inflammatory cytokines. (A) Frequencies of classical monocytes in peripheral blood from SCA patients undertaking or not hydroxyurea were tested for correlations with frequencies of monocytes expressing indicated markers after LPS stimulation in vitro. Data were compared using the Spearman correlation rank test. (B) Spearman correlations between frequency of monocytes subsets and frequency of monocytes expressing IL-1 β, IL-6, IL-8, TF, or TNF-α in SCA patients. HU group n = 17 and no HU group n = 20. Bars represent the strength of correlation (r values). Red bar indicates statistically significant correlation (p < 0.05 after adjustment for multiple comparisons) while grey bars were nonsignificant.