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. 2019 Oct 15;10:4678. doi: 10.1038/s41467-019-12113-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Elevated blood pressure in Clcn2^op mice. a, b Systolic (a) and diastolic (b) blood pressure (BP) measured by telemetry in Clcn2^+/+ (+/+, circles, males: n = 6, females: n = 5), Clcn2^+/op (+/op, squares, n = 5 of each sex) and Clcn2^op/op mice (op/op, triangles, males: n = 5, females: n = 6) fed with control diet and sub-grouped by sex (males, left; females, right). Single values represent the mean blood pressure of an individual mouse measured over 7 consecutive days. Error bars, mean ± SEM. Statistical significance (analyzed separately by sex and compared to Clcn2^+/+) is shown above the groups: **p < 0.01 (Kruskal–Wallis test, Dunn’s multiple comparison test)