Table 1.

Blood electrolyte concentrations and pH of WT, Clcn2^+/op, and Clcn2^op/op mice

Sex	Genotype	n	Na+	K+	Cl−	pH	HCO−3
m	Clcn2 +/+	8	149.1 ± 0.6	3.6 ± 0.2	114.4 ± 2.1	7.25 ± 0.04	22.2 ± 2.1
m	Clcn2 +/op	12	150.2 ± 1.2	3.7 ± 1.0	115.3 ± 2.1	7.25 ± 0.05	20.8 ± 2.7
m	Clcn2 op/op	11	150.6 ± 1.5*	2.9 ± 0.3****	112.2 ± 3.0	7.29 ± 0.05	22.9 ± 2.4
f	Clcn2 +/+	8	149.1 ± 1.0	3.4 ± 0.3	114.1 ± 2.5	7.27 ± 0.04	20.9 ± 1.8
f	Clcn2 +/op	11	149.5 ± 2.2	3.0 ± 0.3	114.7 ± 2.7	7.27 ± 0.04	21.9 ± 1.5
f	Clcn2 op/op	10	150.4 ± 1.8	2.6 ± 0.2***	114.3 ± 1.6	7.27 ± 0.04	21.4 ± 1.6

m male, f female. Ion concentrations in mM. n, number of mice. Significant difference with reference to Clcn2^+/+: *p < 0.05, ***p < 0.001, **** p < 0.0001; Mean values ± SD; Kruskal–Wallis test, Dunn’s multiple comparison test