Table 4.
Use of mean weight at exposure for macrolides and beta-lactams compared to actual weight at exposure to calculate the number of animal daily doses (nADD) of the 2 antimicrobial classes.
| Parenteral antimicrobial drug | ADDkg (mg/kg/day) | Mean weight (kg) | Standard ADD (mg/day) | Antimicrobial used (mg) | nADD (mean weight) | nADD (actual weight) | Variation (%) |
|---|---|---|---|---|---|---|---|
| Macrolides | |||||||
| Tulathromycin | 0.83 | 267 | 223 | 400,310,350 | 1,799,148 | 1,869,247 | −3.8 |
| Tilmicosin | 3.33 | 267 | 890 | 189,139,740 | 212,517 | 214,741 | −1.0 |
| Gamithromycin | 2.00 | 267 | 534 | 15,009,300 | 28,107 | 28,274 | −0.6 |
| Tildipirosin | 1.33 | 267 | 356 | 3,578,760 | 10,053 | 9,195 | 9.3 |
| Overall macrolides | 2,049,825 | 2,121,457 | −3.4 | ||||
| Beta-lactams | |||||||
| Ceftiofur hydrochloride or sodium | 1.10 | 484 | 532.4 | 113,460,385 | 213,111 | 213,103 | 0.0 |
| Ceftiofur crystalline free acid | 2.20 | 484 | 1,065 | 6,793,000 | 6,378 | 7,589 | −15.9 |
| Procaine penicillin | 6.67 | 484 | 3,227 | 4,334,700 | 1,343 | 1,649 | −18.6 |
| Overall beta-lactams | 220,832 | 222,341 | −0.68 | ||||