Table 2.
Role of mTOR signaling in female reproductive cells and organs.
| Cell type | Proposed function | Species | Proposed mediator | References |
|---|---|---|---|---|
| Oocyte | Folliculogenesis | Mouse | No data. | (14, 49, 51, 52, 57) |
| Maturation | Mouse, porcine, bovine | eIF4E, Rho GTPases | (39, 75–78, 83) | |
| Ovarian aging | Mouse | No data. | (17, 111) | |
| Granulosa cells | Folliculogenesis | Rat, mouse | HIF-1α | (49, 64–66) |
| FSH induced-proliferation | Rat | Cyclin D | (85, 86) | |
| Luteal granulosa cells | Steroidogenesis | Human; not applicable for bovine | Cyp11a1, Hsd3b1, Star | (92, 93) |
| Autophagy (proven to unrelated) | Rats | - | (95, 97) | |
| Primordial follicle granulosa cells | Folliculogenesis | Mouse | KITL | (59) |
| Theca-interstitial cells | LH/hCG induced proliferation | Rat | CDK4, Cyclin D, PCNA | (89) |
| Steroidogenesis | Rat | CREB, Cyp11a1, Hsd3b1, Cyp17a1 | (15) | |
| Hypothalamus | Puberty onset | Mouse | Kiss 1 | (16) |
| Embryo | Embryo development | Mouse | No data | (19, 128–131) |
| Embryo differentiation | Mouse, human | No data | (133–138) | |
| Endometrium | Proliferation; apoptosis; autophagy | Mouse, human | No data | (18, 112–116) |
| Implantation | Mouse | NO | (120, 121) | |
| Placentation | Porcine | No data | (122, 123) |