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. 2019 Oct 9;6:99. doi: 10.3389/fmolb.2019.00099

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Copyright © 2019 Lim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SHG for imaging the central nervous system (CNS). (A) Tubulin heterodimer (PDB: 1TUB) with peptide bonds (magenta rods) in microtubule lattice (PDB: 5SYF), which are uniformly oriented in the axon. (B) The mossy fibers in an acute slice of the hippocampus imaged by SHG (reproduced from Dombeck et al., 2003). (C) The retinal nerve fiber bundles in the fresh wholemount retina of glaucoma-developing DBA mouse visualized by SHG. Dashed lines, characteristic sectorial degeneration of glaucoma (redrawn from Sharoukhov et al., 2018). (D,E) SHG intensity for collagen (D) and microtubules (E), respectively, and SHG polarization anisotropy (pSHG) corresponding to the dashed lines as a function of the polarization angle (redrawn from Sharoukhov and Lim, 2016). (F) SHG anisotropy of microtubule changes upon KIF5C binding. Red line, the best fit to the modified Hill equation (redrawn from Shima et al., 2018).