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. 2019 Oct 9;10:2262. doi: 10.3389/fmicb.2019.02262

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Copyright © 2019 Yao, Ma, Cai, Raza, Bai, Wang, Zhang, Ma and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of predicted KEGG pathways of larvae and Spearman correlation analysis. The inferred metabolic pathways are shown with carbohydrate metabolism (A), fructose and mannose metabolism (B), pentose phosphate pathway (C), and glycolysis/gluconeogenesis (D). Spearman correlation analysis between the carbohydrate metabolic pathways and bacteria (taxonomic breakdown at the family level) that vary significantly during the development of larvae is presented in heatmaps (E). Multiple comparisons were performed with one-way analysis of variance and Tukey’s post hoc test. Different letters indicate a significant difference between different samples (p < 0.05). ^∗p < 0.05 and ^∗∗p < 0.01, calculated by Student’s t-test. In heatmaps, blue represents negative correlation between gene expression and bacterial genus, and red represents a positive correlation, ^∗P < 0.05.