Table 3.
Tracheal and kidney histopathology lesion scores at 7 days post challenge.
| Vaccination regime (1:14 day old) | Tracheaa | Kidneya | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Deciliation | Epithelial degeneration | Glandular epithelium Hyperplasia | Hemorrhage | Degeneration | Necrosis | Renal nephrosis | Renal casts | Hemorrhage | |
| IB-M41: IB-Var2 | 0 | 0 | 1 | 0 | 1 | 0.5 | 0.3 | 0.5 | 0 |
| IB-Var2: IB-Var2 | 0 | 0 | 1 | 0 | 1 | 0.5 | 0.5 | 1 | 1 |
| IB-Var2: IB-M41 | 0 | 0 | 1 | 0 | 0 | 0.5 | 1 | 0 | 1 |
| IB-Ma5: IB-793B | 1 | 0.4 | 1 | 0 | 1 | 0.5 | 1.5 | 1 | 0 |
| IB-793B: IB-793B | 1.3 | 1.7 | 1 | 0 | 0 | 0.5 | 1.2 | 0 | 1 |
| IB-793B: IB-Ma5 | 0.5 | 1 | 1 | 0 | 1 | 0.7 | 1.2 | 0 | 1 |
| Challenge control | 2.5 | 2.7 | 3 | 3 | 2.3 | 3 | 3 | 1 | 1 |
| Negative control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
a
Lesion scoring was done according to Lee et al. (23), kidney lesions were scored as 0 for normal, 1 for focal lesions, 2 for multifocal lesions, and 3 for diffuse lesions.