Skip to main content
. 2019 Oct 9;10:2339. doi: 10.3389/fimmu.2019.02339

Figure 3.

Figure 3

Defibrotide (DF) has an anti-inflammatory effect on endothelial cells (ECs) activated and injured after exposure to acute graft-vs.-host disease (aGVHD) serum. Representative images of (A) vascular cell adhesion molecule 1 (VCAM-1) and (B) intercellular adhesion molecule 1 (ICAM-1) expression on EC surfaces in response to aGVHD serum collected on the day of onset in the absence (GVHD-NoDF) or presence of DF (prophylaxis and treatment, GVHD + DF-PT; treatment, GVHD + DF-T). An image representative of results with NoGVHD medium is also included. Bar diagrams show the quantitative analysis of VCAM-1 and ICAM-1 for GVHD-NoDF (black bars), GVHD + DF-PT (gray bars), GVHD + DF-T (dashed bars), and NoGVHD (white bars). Values represent mean ± SEM of MFI from eight different experiments. *P < 0.05, **P < 0.01. Original magnification, 400× for all micrographs.