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. 2019 Oct 9;10:2339. doi: 10.3389/fimmu.2019.02339

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Copyright © 2019 Martinez-Sanchez, Hamelmann, Palomo, Mir, Moreno-Castaño, Torramade, Rovira, Escolar, Cordes, Kalupa, Mertlitz, Riesner, Carreras, Penack and Diaz-Ricart.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Defibrotide (DF) attenuates the increase in VE-cadherin expression on the surface of endothelial cells (ECs) exposed to acute graft-vs.-host disease serum. VE-cadherin staining in ECs exposed to aGVHD serum in the absence (GVHD-NoDF) or presence of DF. An image representative of results with NoGVHD medium is also included. Bar diagrams show the quantitative analysis of VE-cadherin expression for GVHD-NoDF (black bar), GVHD + DF-PT (gray bar), GVHD + DF-T (dashed bar), and NoGVHD (white bar). Values indicate the mean ± SEM of MFI from eight different experiments. *P < 0.05. Original magnification, 400× for all micrographs.