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. 2019 Oct 9;10:1170. doi: 10.3389/fphar.2019.01170

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Copyright © 2019 Prats-Ejarque, Lu, Salazar, Moussaoui and Boix

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depiction of the main interactions identified by molecular dynamics according to the two main family classes (mammalian versus non-mammalian RNases). In dark and light red, the main and secondary specific interactions characteristic for either mammalian or non-mammalian RNases and in grey, the other interactions observed in all the RNases analyzed. Representative icon labels for humans and fishes illustrate the predominant interaction mode for each RNase class. Asn¹ corresponds to Asn71 and Asn² to Asn 67 in RNase A.