Table 3.
Allele and genotype frequencies of rs3764435 and PD risk estimation by sex.
| Allele frequency in Males | Genotypic frequency in Males | Odds ratio [CI 95%]* | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control n (%) | PD n (%) | p | Control n (%) | PD n (%) | p | Models | p | |||
| C+ | 98 (54%) | 50 (41%) | 0.025 | AA | 19 (21%) | 18 (30%) | 0.024 | Codominant | ||
| AA vs. AC | 0.86 [0.39–1.88] | 0.714 | ||||||||
| AA vs. CC | 0.27 [0.09–0.79] | 0.017 | ||||||||
| AC | 44 (49%) | 36 (59%) | Dominant | |||||||
| AA vs. AC+CC | 0.64 [0.30–1.37] | 0.24 | ||||||||
| CC | 27 (30%) | 7 (11%) | Recessive | |||||||
| AA+AC vs. CC | 0.30 [0.12–0.75] | 0.011 | ||||||||
| Allele frequency in Females | Genotypic frequency in Females | |||||||||
| Control n (%) | Case n (%) | p | Control n (%) | Case n (%) | p | |||||
| C+ | 89 (50%) | 53 (45%) | 0.401 | AA | 22 (25%) | 15 (25%) | 0.266 | Codominant | ||
| AA vs. AC | 1.18 [0.53–2.61] | 0.68 | ||||||||
| AA vs. CC | 0.61 [0.22–1.71] | 0.35 | ||||||||
| AC | 43 (48%) | 35 (59%) | Dominant | |||||||
| AA vs. AC+CC | 0.99 [0.46–2.12] | 0.98 | ||||||||
| CC | 23 (26.2) | 9 (16%) | Recessive | |||||||
| AA+AC vs. CC | 0.54 [0.22–1.31] | 0.17 | ||||||||
*
Models adjusted by age. *Bold type reflects statistically significant values.