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. 2019 Oct 9;9:1010. doi: 10.3389/fonc.2019.01010

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Copyright © 2019 Iqbal, Nguyen, Hangel, Motyka, Bogner and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An in vivo example of a healthy volunteer is used to demonstrate the potential application for the D-UNet. The experimental high resolution SI (HRSI) data was acquired at 128x128 resolution using an accelerated acquisition protocol (20). This data was then down-sampled to produce 32x32 low resolution SI (LRSI) metabolite maps for Cr, NAA, Glu, Gln, Ch, and mI. Together with the T1w image, the low resolution metabolite images were used to reconstruct high resolution spectroscopic images (Recon) using the 32x32 D-UNet model. The difference maps between the Recon and HRSI images (Diff) are also shown.