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. 2007 Jul 4;27(27):7094–7104. doi: 10.1523/JNEUROSCI.0174-07.2007

Figure 1.

Figure 1.

CNTF reduces glucose uptake in vivo. A, Vimentin immunostaining of rat brain sections after intrastriatal injection of lentiviruses encoding either CNTF or LacZ. CNTF induces the expression of vimentin compared with the control striatum injected with lenti-LacZ. B, Measurement of striatal FDG uptake in vivo was performed using the autoradiographic technique. A decrease in FDG uptake (mean of −17%) is observed in the whole lenti-CNTF-injected striatum. There is no significant difference between Veh and lenti-LacZ-injected striata for FDG uptake. C, Example of an FDG–PET scan obtained at 4 months after lenti-CNTF injection. After image reconstruction, PET scans were overlaid with anatomical magnetic resonance images for drawing regions of interest from striatum (red: LacZ; blue: CNTF). The curve represents a typical time course of FDG accumulation in both regions and shows a reduced FDG uptake in the CNTF-injected striatum. Data are expressed as mean ± SEM; ***p < 0.001; Student's paired t test; n = 6 per group.