Skip to main content
. 2007 Jul 4;27(27):7141–7153. doi: 10.1523/JNEUROSCI.4599-06.2007

Figure 5.

Figure 5.

Enhanced receptor-mediated endocytosis caused by exogenous expression of APP–BP1 or APP(V642I) in neurons is inhibited when APP binding to APP–BP1 is blocked but not when the neddylation pathway is blocked. Primary neurons coexpressing APP–BP1 (145–251) together with APP–BP1 or APP(V642I) do not show an increase in receptor-mediated endocytosis, as indexed by transferrin uptake, which is observed in neurons expressing APP–BP1 or APP(V642I) alone. In contrast, neurons coexpressing Ubc12(C111S) together with APP–BP1 or APP(V642I) retain the enhanced receptor-mediated endocytosis caused by these proteins. Scale bar, 10 μm.