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. 2007 Jul 4;27(27):7141–7153. doi: 10.1523/JNEUROSCI.4599-06.2007

Figure 9.

Figure 9.

Expression of FAD mutants of presenilin does not affect the number or size of Rab5-positive structures in neurons. Primary neurons were infected with HSV vectors expressing either of two presenilin 1 mutations (M146L or A280E) or APP(V642I), fixed, and stained with rabbit polyclonal anti-Rab5. The cells expressing either of the two presenilin 1 mutations did not show an increase in the number or size of Rab5-positive structures relative to those observed in cells expressing APP(V642I). Each panel shows a single neuron. Scale bar, 5 μm.