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. 2019 Oct 9;9:1029. doi: 10.3389/fonc.2019.01029

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Copyright © 2019 Wang, Yu, Ouyang, Zhao, Yao, Guan, Tong, Chen and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG pathway enrichment analysis for negatively correlated miRNA-mRNA. (A) The top enriched KEGG pathways are shown in the bubble chart. The Y-axis represents the KEGG pathways, and the X-axis represents the rich factor (rich factor = amount of differential expressed genes enriched in the pathway/amount of all genes in the background gene set). The color and size of the bubble represent enrichment significance and the number of genes enriched in the pathway, respectively. (B) Network diagram of top enriched KEGG pathways for the negatively correlated miRNA-mRNA. DEG_UP: up-regulated differential expressed genes; DEG_Down: down-regulated differential expression genes.