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Sex subgroup analysis for diagnostic differentiation between patients with CRC and controls. (A) ROC curves for each of the four biomarkers in the male subgroup. (B) ROC curve for the four biomarkers combined in the male subgroup. (C) Sensitivity and specificity of the combined diagnostic test in the male subgroup. (D) Youden index for the combined diagnostic test in the male subgroup. (E–H) Equivalent results for diagnostic tests in the female subgroup.
