Table 2.

Normal changes in immune molecules in normal pregnancy.

Immune pathway	Normal pregnancy
Th1, Th2 balance	Th2 shift
IL-4, IL-6, and IL-10	Elevated
TNF-α, INF-γ, and IL-2	Reduced
Th17	Reduced
HLA-G	Elevated
NK cells	Elevated
IFN	Reduced IFN-γ
T-reg cells	Elevated

Th, T-helper; HLA-G, major histocompatibility complex; NK, natural killer; IFN, interferons; TNF, tumor necrosis factor; T-reg, T regulatory.