Table 1.
Synthesis of Findings Featuring Type of Structural Neurobiological Abnormality Observed in Patients With Delirium.
| Study | Design | Sample | Neurologic Process | Imaging Technique | Structural Neurobiological Abnormality | ||||
|---|---|---|---|---|---|---|---|---|---|
| Impaired White Matter Integrity | Brain Atrophy | Ischemic Lesions | Edema | Inflammation | |||||
| Bourgeois, Hategan, Ford, Tisi, and Xiong (2015) | Cross sectional | 45 patients | Delirium | CT | X | ||||
| Brown et al. (2015) | Cohort | 79 CICU patients | Delirium | MRI | X | ||||
| Gunther et al. (2012) | Cohort | 47 ICU patients | Delirium | MRI | X | ||||
| Morandi et al. (2010) | Case series | 8 ICU patients | Delirium | MRI | X | ||||
| Morandi et al. (2012) | Cohort | 47 ICU patients | Delirium | MRI | X | ||||
| Piazza, Cotena, De Robertis, Caranci, and Tufano (2009) | Case series | 4 ICU patients | SAE | MRI | X | X | |||
| Polito et al. (2013) | Cohort | 71 ICU patients | SAE | MRI | X | X | |||
| Rolandi et al. (2018) | Cohort | 16 orthopedic patients | Delirium | MRI | X | X | |||
| Suchyta, Jephson, and Hopkins (2010) | Cohort | 64 ICU patients | Neurologic dysfunction | CT, MRI | X | X | X | X | |
| Sutter et al. (2015) | Cohort | 146 ICU patients | Neurologic dysfunction | MRI | X | X | X | ||
| Yager et al. (2011) | Cohort | 23 BMT patients | Delirium | MRI | X | ||||
Note. BMT = bone marrow transplant; CICU = cardiac intensive care unit; CT = computed tomography; ICU = intensive care unit; MRI = magnetic resonance imaging; SAE = sepsis-associated encephalopathy.