Table 1.

Summary of results of open-label single-arm trials of FMT in IBS.

References	Country	Sample size (n)	Route of FMT administration	Follow-up	Results
Morken et al. 200925	Norway	10	Gastroduodenoscopy	12 months	Antibiotics and bacteriotherapy were ineffective in post-giardiasis IBS-like symptoms
Pinn et al. 201418	USA	13	Gastroduodenoscopy	11 months	70% of patients experienced resolution of IBS symptoms after FMT
Cruz et al. 20157	Germany	9	Colonoscopy	3 months	FMT was beneficial, even though transient; there were profound microbiome changes in IBS-D patients
Hong et al. 201612	Korea	10	Colonoscopy	12 and 26 weeks	Symptom improvement after FMT in 80% of patients; however, those who showed significant improvement in IBS severity scores during the first month returned to their pre-FMT state after 3 months
Syzenko et al. 201626	Ukraine	12	Colonoscopy	NR	Significant rate of clinical improvement in refractory IBS symptoms after FMT (p ≤ 0.01)
Mizuno et al. 201717	Japan	10	Colonoscopy	4 weeks	FMT improved stool form and depressed mood; Bifidobacterium-rich donor feces was related to successful FMT
Holvoet et al. 201711	Belgium	12	NR	12 months	75% of patients had adequate relief of global IBS symptoms and abdominal bloating; successful donors tended to have higher baseline counts of Streptococcus
Mazzawi et al. 201616	Norway	16	Gastroduodenoscopy	1, 3, 12, and 28 weeks	FMT induced significant changes in gut microbiota and symptom relief in IBS patients

FMT: fecal microbiota transplant; IBS: irritable bowel syndrome; IBS-D: IBS with diarrhea; NR: Not reported.