Table 3.

Multivariate logistic regression analysis showing association of disease extension and extent progression with different step-up approaches (expressed as: n (%); OR (95%CI); p value). Bold values indicate they are statistically significant.

Disease extension	IMM (n = 122)	Biological therapy (n = 72)	Colectomy (n = 16)
E1 (proctitis)	Reference	Reference	n = 0 (0%)
E2 (left-sided)	n = 37 (30%); OR 2.07 (1.04–4.11); p = 0.04	n = 21 (29%); OR 1.77 (0.80–3.70); p = 0.17	Reference
E3 (extensive)	n = 58 (48%); OR 2.93 (1.45–5.89); p < 0.01	n = 33 (46%); OR 2.74 (1.24–6.09); p = 0.02	n = 15 (94%); OR 9.28 (1.14–75.31); p = 0.04
Extent progression	n = 35 (47%); OR 5.19 (2.68–10.04); p < 0.01	n = 23 (31%); OR 4.37 (2.15–8.89); p < 0.01	n = 1 (2%); OR 0.63 (0.07–5.76); p = 0.68

CI: confidence interval; IMM: immunomodulators; OR: odds ratio.