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Number of patients with unacceptable to neutral abdominal pain (Likert scale 1–4) at evaluation time points. Day 28: end of first-line treatment; Day 56: end of crossover treatment; Day 86: after 30 days' follow-up; Day 116: after 60 days' follow-up. Broken lines indicate follow-up period. PPT: pea protein and tannins from grape seed extract; XG: xyloglucan; XOS: xylo-oligosaccharides.
