Table 3.
Network meta-analysis results
| a. Network meta-analysis results for five outcomes | |||||
| OS | |||||
| nCRTS-ENI | |||||
| 0.84(0.62–1.1) | nCRTS-IFI | ||||
| 0.73(0.55–0.97) | 0.87(0.73–1.0) | nCTS | |||
| 0.63(0.48–0.83) | 0.75(0.66–0.86) | 0.87(0.77–0.97) | S-alone | ||
| LR | |||||
| nCRTS-IFI | |||||
| 0.74(0.37–1.5) | nCRTS-ENI | ||||
| 0.59(0.37–0.94) | 0.61(0.30–1.3) | nCTS | |||
| 0.43(0.30–0.60) | 0.58(0.31–1.1) | 0.79(0.59–1.1) | S-alone | ||
| DM | |||||
| nCRTS-IFI | |||||
| 1.0(0.54–1.9) | nCRTS-ENI | ||||
| 0.92(0.60–1.4) | 0.90(0.50–1.6) | nCTS | |||
| 0.79(0.57–1.1) | 0.76(0.44–1.3) | 0.85(0.64–1.2) | S-alone | ||
| POM | |||||
| S-alone | |||||
| 0.99(0.68–1.4) | nCTS | ||||
| 0.56(0.33–0.92) | 0.56(0.30–1.0) | nCRTS-IFI | |||
| 0.56(0.27–1.1) | 0.56(0.27–1.2) | 1.0(0.41–2.4) | nCRTS-ENI | ||
| R0 resection | |||||
| S-alone | |||||
| 0.57(0.40–0.80) | nCTS | ||||
| 0.16(0.09–0.28) | 0.28(0.14–0.53) | nCRTS-IFI | |||
| 0.16(0.07–0.34) | 0.29(0.13–0.59) | 1.0(0.39–2.6) | nCRTS-ENI | ||
| b. Network meta-analysis results of OS for four subgroups | |||||
| ESCC | |||||
| nCRTS-IFI | |||||
| 0.83(0.47–1.5) | nCRTS-ENI | ||||
| 0.78(0.63–0.96) | 0.80(0.43–1.5) | nCTS | |||
| 0.50(0.38–0.68) | 0.61(0.35–1.0) | 0.76(0.57–1.0) | S-alone | ||
| EAC | |||||
| nCRTS-ENI | |||||
| 0.70(0.37–1.3) | nCRTS-IFI | ||||
| 0.65(0.38–1.1) | 0.93(0.71–1.3) | nCTS | |||
| 0.50(0.28–0.87) | 0.72(0.58–0.91) | 0.78(0.62–0.93) | S-alone | ||
| RT with dose of ≥40Gy/<40Gy | |||||
| nCRTS-ENI ≥ 40Gy | |||||
| 0.90(0.59–1.4) | nCRTS-IFI ≥ 40Gy | ||||
| 0.89(0.54–1.5) | 0.99(0.70–1.4) | nCRTS-ENI < 40Gy | |||
| 0.71(0.48–1.1) | 0.79(0.65–0.96) | 0.80(0.58–1.1) | nCTS | ||
| 0.68(0.43–1.1) | 0.76(0.56–1.0) | 0.76(0.51–1.1) | 0.96(0.72–1.3) | nCRTS-IFI < 40Gy | |
| 0.62(0.43–0.92) | 0.70(0.59–0.82) | 0.70(0.51–0.96) | 0.88(0.78–0.99) | 0.92(0.71–1.2) | S-alone |
| RT with technique of 3DRT/2DRT | |||||
| nCRTS-ENI-3DRT | |||||
| 0.74(0.46–1.2) | nCRTS-IFI-2DRT | ||||
| 0.68(0.42–1.1) | 0.92(0.68–1.2) | nCRTS-IFI-3DRT | |||
| 0.58(0.34–0.99) | 0.87(0.57–1.3) | 0.94(0.63–1.4) | nCRTS-ENI-2DRT | ||
| 0.61(0.39–0.94) | 0.83(0.64–1.1) | 0.90(0.72–1.1) | 0.96(0.66–1.4) | nCTS | |
| 0.53(0.34–0.80) | 0.72(0.57–0.88) | 0.78(0.64–0.94) | 0.82(0.58–1.2) | 0.86(0.76–0.98) | S-alone |
Abbreviations: OS Overall survival, LR Locoregional recurrence, DM Distant metastases, POM Post-operative mortality, nCRTS Neoadjuvant chemoradiotherapy plus surgery, nCTS Neoadjuvant chemotherapy plus surgery, S Surgery, RT Radiotherapy, ENI Elective nodal irradiation, IFI Involved-field irradiation, ESCC Esophagus squamous cell carcinoma, EAC Esophagus adenocarcinoma, 2D Two-dimensional, 3D Three-dimensional
Significant results are in bold