Fig. 7.
PH overcomes the Sor resistance in HepG2SR and Huh7SR xenografts in vivo. a PH significantly reduced tumor growth in SR-HCCs xenografts. When tumors reached 100 mm3, the mice were treated with PH, Sor or both and then tumor growth was measured every 3 days. b Tumor weight was measured on day 30 after tumor excision. c The protein levels of p-STAT3 and its downstream proteins were determined by Western blot. d The in vivo SHP-1 phosphatase activity. e Immunohistochemical staining of CD31, p-STAT3, cleaved caspase-3, Ki67 and TUNEL in HepG2SR and Huh7SR xenografts. Magnification: ×200. Data represents mean values from five random fields per tumor section. Scale bar, 50 μm. Mean values ± SD (bars) are shown. *p < 0.05, and **p < 0.01 compared to control