Table 2.
Multivariate-adjusted Cox proportional hazard regression models predicting OS and RFS classified by AJCC 8th edition N stage, LNR, and LODDS
| Number of patients | OS | RFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Median OS, months | HR (95% CI) a | p | AIC | Bootstrap-corrected C index | Median RFS, months | HR (95% CI) a | p | AIC | Bootstrap-corrected C index | ||
| pN (AJCC 8th) | |||||||||||
| 0 | 150 | 50.8 | 1 | < 0.001 | 2003.0 | 0.57 | 23.5 | 1 | < 0.001 | 2274.3 | 0.57 |
| 1 | 135 | 27.0 | 1.58 (1.14-2.19) | 15.0 | 1.34 (0.98-1.83) | ||||||
| 2 | 66 | 22.5 | 2.00 (1.36-2.95) | 10.1 | 2.01 (1.38-2.92) | ||||||
| LNR | |||||||||||
| 0 | 150 | 50.8 | 1 | < 0.001 | 2005.9 | 0.65 | 23.5 | 1 | 0.001 | 2278.4 | 0.63 |
| > 0 to ≤0.2 | 141 | 26.3 | 1.62 (1.17-2.23) | 13.5 | 1.39 (1.02-1.88) | ||||||
| > 0.2 to ≤0.4 | 23 | 21.5 | 1.66 (0.90-3.01) | 11.0 | 1.80 (1.02-3.18) | ||||||
| > 0.4 | 37 | 21.4 | 2.05 (1.31-3.20) | 9.2 | 1.90 (1.23-2.96) | ||||||
| LODDS | |||||||||||
| Quantile 1 | 89 | 48.8 | 1 | 0.002 | 2008.8 | 0.64 | 20.6 | 1 | 0.009 | 2277.5 | 0.63 |
| Quantile 2 | 91 | 34.8 | 1.26 (0.84-1.91) | 17.3 | 1.17 (0.79-1.72) | ||||||
| Quantile 3 | 85 | 27.4 | 1.46 (0.97-2.20) | 15.4 | 1.24 (0.84-1.84) | ||||||
| Quantile 4 | 86 | 22.0 | 1.90 (1.25-2.87) | 10.1 | 1.78 (1.21-2.62) | ||||||
OS overall survival, RFS recurrence-free survival, AIC akaike information criterion, AJCC American Joint Committee on Cancer, LNR lymph-node ratio, LODDS log odds of positive lymph nodes, CA 19-9 carbohydrate antigen 19-9
a HR adjusted with the histologic grade, lymphovascular invasion, perineural invasion, pathologic T stage, and preoperative CA19-9 ≥ 100 U/mL