Grade	Morphology
0	Normal myocardial ultrastructural morphology
0.5	Not completely normal but no evidence of anthracycline-specific damage
1	Isolated myocytes affected and/or early myofibrillar loss; damage to < 5% of all cells
1.5	Changes similar to those in grade 1 except damage involves 6–15% of all cells
2	Clusters of myocytes affected by microfibrillar loss and/or vacuolization, with damage 16–25% of all cells
2.5	Many myocytes (26–35% of all cells) affected by vacuolization and/or myofibrillar loss
3	Severe, diffuse myocyte damage (>35% of all cells)