Table 2.
Subject demographic, clinical characteristics, and clinical outcomes by severity of community-acquired pneumonia (CAP)
| Severe CAP (n = 50) |
Non-severe CAP (n = 44) |
p-value | |
|---|---|---|---|
| Age, y | 70.9 ± 14.8 | 68.2 ± 20.3 | .46 |
| Gender (Female) | 18 (36) | 19 (43.2) | .48 |
| Mechanical ventilation | 36 (72) | 0 | <.001* |
| Minor criteria ≥3a | 14 (28) | 0 | <.001* |
| Comorbid conditions: | |||
| None / Single / Multiple | 9 (18) / 21 (42) / 20 (40) | 17 (38.6) / 17 (38.6) / 10 (22.7) | .05* |
| Prior antibiotic therapyb | 21 (42) | 22 (50) | .44 |
| ECOG scale ≥2c | 32 (64) | 22 (50) | .17 |
| Enteral tube feeding | 6 (12) | 3 (6.8) | .49 |
| HCAPd | 18 (36) | 12 (27.3) | .36 |
| Pleural effusion | 3 (6) | 8 (18.2) | .07 |
| Albumin, g/dL | 2.8 ± 0.6 | 3.1 ± 0.5 | .01* |
| Globulin, g/dL | 3.7 ± 0.8 | 4.1 ± 0.6 | .001* |
| Treatment failure | 23 (46) | 4 (9.1) | <.001* |
| Death | 14 (28) | 4 (9.1) | .02* |
| Unfavorable outcomee | 25 (50) | 6 (13.6) | <.001* |
| Length of stay in hospital, df | 15.5 ± 12.8 | 8.3 ± 4.6 | .003* |
| Hospital-free day, d g | 11.6 ± 9.9 | 19.7 ± 7.7 | <.001* |
Data are presented as mean ± SD or n (%), unless otherwise stated. aIDSA/ATS 2007 minor criteria7. bPrior antibiotic therapy: systemic antibiotic use in the 90 days prior to this admission. cECOG scale: Eastern Cooperative Oncology Group scale of performance status. dHCAP: Healthcare–associated pneumonia. eUnfavorable outcome includes treatment failure or death during hospital admission. f Length of stay in hospital in patients who survived to hospital discharge. gNumber of days from admission to day 30 that the patient was not admitted to the hospital. *Statistically significant difference