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. 2019 Oct 15;20:497. doi: 10.1186/s12859-019-3099-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The number of correctly predicted contacts according to the conservation grades of the two nucleotides involved in the contact for all tested riboswitch RNAs. The contacts are divided into variable type (both nucleotides with conservation-grade 1–3), conserved type (both nucleotides with conservation-grade 7–9), and others, respectively. a, b, c, d, e, and f The performance of DIRECT (yellow) in comparison to DCA (blue) is considerably better for the variable contacts and only slightly improved for the conserved contacts