Figure 1.

Classical view of the SV cycle. Action potentials trigger fusion of SVs at the active zone. After formation of the fusion pore, resulting in neurotransmitter release, two options are possible: the pore can reclose via kiss-and-run (K&R) or it can expand irreversibly, leading to full collapse. Compensating for full-collapse fusion, specific SV proteins are recruited by adaptor proteins at the periactive zone, triggering CME. Dynamin mediates vesicle scission, after which SVs are uncoated and refilled with neurotransmitters before being returned to the vesicle cluster.